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The Cystinuria Committee has helped coordinate Cystinuria Clinics, which have been an asset to the current research being done at the University of Pennsylvania because family members of affected dogs have submitted samples and new dogs have been added to the research study. 

It is encouraged that all Regional Mastiff Clubs consider sponsoring Cystinuria Clinics at your special events and Supported Shows.

When dogs are diagnosed with Cystinuria we ask that the owners contact their breeders, the stud dog owners, and their puppy buyers to help coordinate participation in the research and to have those dogs Cystinuria tested as well.  Since cystine levels fluctuate in Mastiffs it is recommended that Mastiffs be retested, especially if they are related to an affected dog or if they are being used for breeding. 

Although UPenn would like to receive urine samples from young dogs to help collect data and to try to determine the earliest age of onset of this disease in Mastiffs, it is very important that Mastiffs are Cystinuria tested at or after 18 to 24 months of age with routine re-testing as this appears to be a late onset disease in Mastiffs.  We will not know which of our dogs are affected unless we test or they show clinical symptoms of the disease.

We would like to thank the breeders and their puppy buyers that have submitted urine, blood and other requested information on your Mastiffs.  The research is dependent on DNA samples and shared information from the Mastiff Community. We continue to need more families to participate and appreciate all of your help! 

A special THANK YOU goes out to those that have had Cystinuria Clinics, to those that have Cystinuria tested their Mastiffs and to those that are participating in the research!

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